Educational Qualifications

National Chemical Laboratory, University of Pune (Pune , Maharashtra, India)


Ahmednagar College (Ahmadnagar , Maharashtra, India)

Professional Experience
Assistant Professor

Department of Chemistry, Panjab University

Awards & Honours
Ramalingaswami Re-entry Fellowship (2015): A re-entry fellowship awarded by the Department of Biotechnology to work on the design and synthesis of new small molecule inhibitors of indoleamine 2,3-dioxygenase (IDO).
National Science Council Fellowship (2009): A postdoctoral research fellowship awarded by National Science Council of Taiwan
Indo-French Sandwich Ph.D. Scholarship (2006): A national scholarship awarded by Science and Technology Service of the Embassy of France in India
Senior Research Fellowship (2005): A national fellowship awarded by the Council of Scientific and Industrial Research (CSIR) New Delhi, India for the Ph.D
Junior Research Scholarship (2004): A national fellowship awarded by LTMT, Mumbai, INDIA for the research work carried out under the supervision of Dr. Vandana S. Pore on the project entitled “Design and synthesis of steroid based anti-fungal agents.”
Books/Chapters of Book Published
Chiral synthesis on polymer support: a combinatorial approach. In Polymeric chiral catalyst design and chiral polymer synthesis; Itsuno, S., Ed.; John Wiley & Sons, Inc., Hoboken, N. J. 2011, Chapter 6, Pages 157-199.

Steroidal conjugates and their pharmacological applications. Curr. Med. Chem. 2006, 13, 813-847.

Bile acid-polyamine conjugates as synthetic ionophores. Arkivoc 2003, 9, 115-125.

Research Paper/Articles Published
New steroidal dimers with antifungal and antiproliferative activity

Journal: Med. Chem. 2004, 47, 1591- 1594.

An efficient method for the synthesis of methyl 11α-amino-3α,7α-diacetoxy-12-oxo-5β-cholan-24-oate

Journal: Tetrahedron 2005, 61, 3605-3612.

Enhancement of HIV infection and induction of syncytium formation by amino functionalized bile acid derivatives

Journal: Med. Chem. 2006, 49, 2652-2655.

Molecular association via halogen bonding and other weak interactions in the crystal structures of 11- bromo-12-oxo-5β-cholan derivatives

Journal: Mol. Structure 2008, 892, 246-253.

Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents

Journal: Bioorg. Med. Chem. Lett. 2008, 18, 5512- 5517.

Pd-catalyzed one-pot chemoselective hydrogenation protocol for the preparation of carboxamides directly from azides

Journal: Tetrahedron Lett. 2010, 51, 3815-3819.

Microwave-assisted divergent synthesis of indolo-fused pyrazino/diazepinoquinoxalinones on PEG support

Journal: Org. Lett. 2010, 12, 2174-2177.

Soluble polymer supported divergent synthesis of tetracyclic benzene-fused pyrazino/diazepino indoles: an advanced synthetic approach to bioactive scaffolds

Journal: Org. Biomol. Chem. 2011, 9, 2925-2937.

Divergent synthesis of unsymmetrical annulated biheterocyclic compound libraries: benzimidazole linked indolobenzodiazepines/quinoxaline

Journal: ACS Comb. Sci. 2011, 13, 391-398.

Discovery of a potent and selective small molecule hGPR91 antagonist

Journal: Bioorg. Med. Chem. Lett. 2011, 21, 3596-3602.

Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain

Journal: Eur. J. Med. Chem. 2011, 46, 3681-3689.

Synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with vinyl side chain

Journal: Chemistry & Biology Interface 2011, 1, 198-208.

RuCl3-TBHP mediated allylic oxidation of ∆8(9) lanosterol derivatives

Journal: Tetrahedron Lett. 2011, 52, 6007-6010.

Design and synthesis of new biprivileged molecular scaffolds: indolo-fused benzodiazepinyl/quinoxalinyl benzimidazoles.

Journal: Chem. Asian J. 2012, 7, 1684-1690

Increase of leishmanicidal and tubercular activities using steroids linked to aminoquinoline

Journal: Org. Med. Chem. Lett. 2012, 2:16, 8 pp. DOI: 10.1186/2191-2858-2-16.

Structure-activity relationships in Human toll-like receptor 2-specific monoacyl lipopeptides

Journal: Med. Chem. 2012, 55, 3353-3363.

Antibacterial activities of Groebke-Blackburn-Bienaymé−derived imidazo[1,2-a]pyridin-3-amines

Journal: Bioorg. Med. Chem. 2012, 20, 5850-5863.

Structure-activity relationships in human toll-like receptor 8-active 2,3- diamino-furo[2,3-c]pyridines.

Journal: Med. Chem. 2012, 55, 8137-8151.

Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.

Journal: PLoS ONE 2012, 7, e43612.

Structure-activity relationships in toll-like receptor 8 agonistic 2-alkylthiazolo[4,5- c]quinolines

Journal: Org. Biomol. Chem. 2013, 11, 1179-1198.

Design and development of stable, water-soluble, human toll-like receptor 2-specific, monoacyl lipopeptides as candidate vaccine adjuvants.

Journal: Med. Chem. 2013, 56, 5885-5900.

Synthesis and antimicrobial activity of novel oxysterols from lanosterol

Journal: Tetrahedron 2013, 69, 11155-11163

Determinants of activity at human Toll-like Receptors 7 and 8: Quantitative structure–activity relationship (QSAR) of diverse heterocyclic scaffolds

Journal: Med. Chem. 2014, 57, 7955-7970.

Research Papers/Articles Presented
Poster Presented on Synthesis of new mimics of squalamine

presented at CRSI’s Fourth National Symposium in Chemistry, 2002, Pune, India.

Poster Presented on Synthesis of squalamine analogues derived from bile acids

presented at CRSI’s Fifth National Symposium in Chemistry, 2003, Chennai, India.

Poster Presented on New steroidal dimers with antifungal and antiproliferative activity

presented at CRSI’s Sixth National Symposium in Chemistry, 2004, Kanpur, India.

Poster Presented on Design and synthesis of steroid based hybrid antifungal agents

presented at CRSI’s Seventh National Symposium in Chemistry, 2005, Kolkata, India

Poster Presented on Structure-activity relationships in human toll-like receptor 8-active 2,3- diamino-furo[2,3-c]pyridines

presented at 245th ACS National Meeting & Exposition, New Orleans, LA, United States, MEDI-283. on 2013-04-07

Qualified Graduate Aptitude Test in Engineering (GATE-2002): Category: Chemical Sciences, conducted by Human Resources Ministry of Government of India in collaboration with Indian Institute of Science (IISc), Bangalore, INDIA.
Patents: Salunke, D. B.; Hazra, B. G.; Pore, V. S.; Bhat, M. K. Bile acid derived steroidal dimers with amphiphilic topology having antiproliferative activity. U.S. Pat. Appl. Publ. (2006), US 20060003974 A1 20060105. IN 2004DE01213 A. Indian Pat. Appl. (2006), IN 2004DE01213 A 20060623.
Patents: Salunke, D. B.; Hazra, B. G.; Pore, V. S.; Nahar, P. B.; Deshpande, M. V. Bile acid derived steroidal dimers with novel amphiphilic topology having antifungal activity. U.S. Pat. Appl. Publ. (2005), US 20050222115 A1 20051006. Indian Pat. Appl. (2009), IN 2005DE00704 A 20090619.
Patents: Salunke, D. B.; Guo, X.; David, S. A. Toll-like receptor 2-agonistic lipopeptides and method of making the same. U.S. Pat. Appl. No. 61/753,690 (Provisional application filed).
Project Work
NCL, Pune, India (Research Assistant): July 2002 – April 2004: Worked on the project entitled “Synthesis of aromataze inhibitors, neuroactive steroids and squalamine” sponsored by Department of Science and Technology (DST), New Delhi and was involved in total synthesis of steroid-polyamine conjugate ‘Squalamine’. Synthesized several squalamine mimics also worked on synthesis of spermine, spermidine and their analogues.

¾ ICSN, CNRS, France. (Graduate Student): September 2006 – February 2007: Worked on self-written project entitled “Design, synthesis and bioevaluation of novel steroidamino acid conjugates as Squalamine and PMB mimics.” Herein, we developed a protocol for the synthesis of various steroidal peptides. The resulted steroidal peptides demonstrated a synergism effect with the known antibiotics. The synergism of the most active compounds greatly improved the activity of fluconazole and erythromycin against C. albicans and E. coli, respectively. Palladium catalyzed chemoselective one-pot reductive transformation of alkyl azides to carboxamides was another key outcome of this project.

University of Kansas, Lawrence (Postdoctoral Researcher): November 2010 – March 2013: Worked on a federal contract entitled “Innate Immune Receptors and Adjuvant Discovery” funded by NIAID, a division of the NIH towards the design and synthesis of potent human (h)TLR 2-specific monoacyl lipopeptides. Recently, in an effort to discover new vaccine adjuvants for neonatal vaccines, an extensive SAR on TLR-8 agonistic 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) was also carried out. Additionally, to explore new chemical space for TLR-7/8 agonists, a diverse library of imidazo[1,2-a]pyridines/pyrazines was synthesized using Groebke-BlackburnBienaymé multicomponent reaction. Few of the library members (3-amino-imidazo[1,2- a]pyridines) were found to be active against Methicillin-resistant Staphylococcus aureus whereas a novel furo[2,3-c]pyridine chemotype was isolated for the first time in this reaction. These new molecules were found to be selective TLR-8 agonistic in cell based NFκB reporter assay.

Professional Association