NCL, Pune, India (Research Assistant): July 2002 – April 2004: Worked on the project entitled “Synthesis of aromataze inhibitors, neuroactive steroids and squalamine” sponsored by Department of Science and Technology (DST), New Delhi and was involved in total synthesis of steroid-polyamine conjugate ‘Squalamine’. Synthesized several squalamine mimics also worked on synthesis of spermine, spermidine and their analogues.
¾ ICSN, CNRS, France. (Graduate Student): September 2006 – February 2007: Worked on self-written project entitled “Design, synthesis and bioevaluation of novel steroidamino acid conjugates as Squalamine and PMB mimics.” Herein, we developed a protocol for the synthesis of various steroidal peptides. The resulted steroidal peptides demonstrated a synergism effect with the known antibiotics. The synergism of the most active compounds greatly improved the activity of fluconazole and erythromycin against C. albicans and E. coli, respectively. Palladium catalyzed chemoselective one-pot reductive transformation of alkyl azides to carboxamides was another key outcome of this project.
University of Kansas, Lawrence (Postdoctoral Researcher): November 2010 – March 2013: Worked on a federal contract entitled “Innate Immune Receptors and Adjuvant Discovery” funded by NIAID, a division of the NIH towards the design and synthesis of potent human (h)TLR 2-specific monoacyl lipopeptides. Recently, in an effort to discover new vaccine adjuvants for neonatal vaccines, an extensive SAR on TLR-8 agonistic 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) was also carried out. Additionally, to explore new chemical space for TLR-7/8 agonists, a diverse library of imidazo[1,2-a]pyridines/pyrazines was synthesized using Groebke-BlackburnBienaymé multicomponent reaction. Few of the library members (3-amino-imidazo[1,2- a]pyridines) were found to be active against Methicillin-resistant Staphylococcus aureus whereas a novel furo[2,3-c]pyridine chemotype was isolated for the first time in this reaction. These new molecules were found to be selective TLR-8 agonistic in cell based NFκB reporter assay.