Expression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line.
Journal: Oncology letters 3 :1079-1082
Curcumin causes promoter hypomethylation and increased expression of FANCF gene in SiHa cell line.
Journal: Molecular and Cellular Biochemistry,365 :29-35
Use of laccase in pulp and paper industry.
Journal: Biotechnology Progress, 28 : 21-32
Characterization of a Glycoside Hydrolase Family 1 β-Galactosidase from Hot Spring Metagenome with Transglycosylation Activity.
Journal: Applied biochemistry and biotechnology 168 (6), 1681-1693
An alkalophilic laccase from Rheinheimera species isolate: Production and biobleaching of kraft pulp.
Journal: Biotechnology progress 28 (6), 1426-1431
N-acyl homoserine lactone mediated interspecies interactions between A.
Journal: Baumannii and P. aeruginosa. Biofouling 28 (8), 813-822
A new esterase, belonging to hormone sensitive lipase family, cloned from Rheinheimera sp. Isolated from industrial effluent.
Journal: Journal of Microbiology and Biotechnology. 21:667-674
Quorum sensing in Acenitobacter : an emerging pathogen.
Journal: Critical Reviews in Microbiology.34,349-360
Research Areas: Natural antipathogenic agents for the control of multiple drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa.
Enzymatic and plant based compounds as quorum quenchers are being studied for therapeutic applications using C.elegans as the model system.
Targeting persister cells formation in A. baumannii and mechanisms underlying persistence.
Reversal of epigenetic DNA hypermethylation of promoter of tumour suppressor genes in cervical cancer
Natural compounds are being screened to target DNMT1, which methylates hemimethylated DNA in a cell and also study the molecular mechanism of hypomethylation.
Industrially important enzymes: Isolation, cloning, characterization and applications of laccase, esterase, xylanase and restriction endonuclease from bacteria.
Technology Transfer: Technology transfer of TspMI a highly stable, quick reaction Type II restriction endonucleases (REBASE Enz Num 7191, thermostable isoschizomer of XmaI) from Thermus sp. manalii (GenBank accession # DQ219467, MTCC strain # 7654) to New England Biolabs, USA.
Area of specialization: Microbial Biotechnology and Cancer Epigenetics.